Significance of load receptor input during locomotion: a review

Abstract

A basic aspect of the neuronal control of quadrupedal locomotion of cat and of bipedal stance and gait of humans concerns the antigravity function of leg extensors. In humans proprioceptive reflexes involved in the maintenance of body equilibrium depend on the presence of contact forces opposing gravity. Extensor load receptors are thought to signal changes of the projection of body's centre of mass with respect to the feet. According to observations in the cat, this afferent input probably arises from Golgi tendon organs and represents a newly discovered function of these receptors in the regulation of stance and gait. From these experiments it can be concluded that during locomotion there is a closing of Ib inhibitory and an opening of Ib extensor facilitatory paths. In humans evidence for a significant contribution of load receptor contribution to the leg muscle activation came from immersion experiments. Compensatory leg muscle activation depends on the actual body weight. Also during gait the strength of leg extensor activation during the stance phase is load dependent. In patients with Parkinson's disease there is a reduced load sensitivity and decreased leg extensor activation, which might contribute to the movement disorder. Recent experiments in paraplegic patients show that the beneficial effects of a locomotor training critically depends on the initial degree of body unloading and reloading during the course of the training period.