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. 2000 Aug;68(8):4802-4.
doi: 10.1128/IAI.68.8.4802-4804.2000.

Dominant nonresponsiveness to Helicobacter pylori infection is associated with production of interleukin 10 but not gamma interferon

P Sutton  1 , T Kolesnikow, S Danon, J Wilson, A Lee
Affiliations
Free PMC article

Dominant nonresponsiveness to Helicobacter pylori infection is associated with production of interleukin 10 but not gamma interferon

P Sutton et al. Infect Immun. 2000 Aug.
Free PMC article

Abstract

Helicobacter pylori-induced gastritis is an essential precursor lesion for the development of peptic ulcers or gastric adenocarcinoma. We demonstrate that nonresponsiveness to H. pylori SS1 infection is dominantly inherited in mice. F(1) hybrid crosses between a nonresponder mouse and three responder strains all possessed the nonresponder phenotype. Secretion of interleukin-10 but not gamma interferon was associated with nonresponsiveness to infection.

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Figures

FIG. 1
FIG. 1
Production of IFN-γ and IL-10 following in vitro stimulation of mice with Helicobacter antigens. Data shown represent the mean ± standard deviation for IFN-γ (a) and IL-10 (b) by enzyme-linked immunosorbent assay. All supernatants from cells cultured in medium alone were negative for both cytokines (not shown). Hf, H. felis; Hp, H. pylori. ∗, significantly less cytokine than the equivalent group of the other two strains (P < 0.05). ■, Uninfected and Hf, stimulated; ▨, Uninfected and Hp stimulated; ░⃞, Hf infected and Hf stimulated; ▤, Hp infected and Hp stimulated.
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