Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2000 Aug;68(8):4815-7.
doi: 10.1128/IAI.68.8.4815-4817.2000.

Polymorphism of repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica

C Boursaux-Eude  1 , N Guiso
Affiliations
Comparative Study

Polymorphism of repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica

C Boursaux-Eude et al. Infect Immun. 2000 Aug.

Erratum in

  • Infect Immun 2000 Dec;68(12):7214

Abstract

Pertactin is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
(A) Structure of the B. bronchiseptica PRN, which harbors two repeated regions (I and II) sequenced in this study. (B and C) Multiple alignments of region I (B) and region II (C).
See this image and copyright information in PMC

References

    1. Arico B, Gross R, Smida J, Rappuoli R. Evolutionary relationships in the genus Bordetella. Mol Microbiol. 1987;1:301–308. - PubMed
    1. Arico B, Miller J F, Roy C, Stibitz S, Monack D, Falkow S, Gross R, Rappuoli R. Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc Natl Acad Sci USA. 1989;86:6671–6675. - PMC - PubMed
    1. Boursaux-Eude C, Thiberge S, Carletti G, Guiso N. Intranasal murine model of Bordetella pertussis infection. II. Sequence variation and protection induced by a tricomponent acellular vaccine. Vaccine. 1999;17:2651–2660. - PubMed
    1. Brennan M J, Li Z M, Cowell J L, Bisher M E, Steven A C, Novotny P, Manclark C R. Identification of a 69-kilodalton nonfimbrial protein as an agglutinogen of Bordetella pertussis. Infect Immun. 1988;56:3189–3195. - PMC - PubMed
    1. Charles I G, Dougan G, Pickard D, Chatfield S, Smith M, Novotny P, Morrissey P, Fairweather N F. Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci USA. 1989;86:3554–3558. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources