Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jul;71(1-2):179-86.
doi: 10.1016/s0378-8741(99)00200-7.

Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark

O A Olajide  1 , S O Awe, J M Makinde, A I Ekhelar, A Olusola, O Morebise, D T Okpako
Affiliations

Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark

O A Olajide et al. J Ethnopharmacol. 2000 Jul.

Abstract

The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei.

PubMed Disclaimer

MeSH terms

LinkOut - more resources