Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Aug;83(2):143-5.
doi: 10.1136/adc.83.2.143.

Intravenous pamidronate in juvenile osteoporosis

N J Shaw  1 , C M Boivin, N J Crabtree
Affiliations

Intravenous pamidronate in juvenile osteoporosis

N J Shaw et al. Arch Dis Child. 2000 Aug.

Abstract

Aims: To investigate the use of the aminobisphosphonate, disodium pamidronate, in children with vertebral osteoporosis.

Methods: Five children (aged 10-15 years) with vertebral osteoporosis who developed compression fractures in the thoracic and/or lumbar spine as a consequence of five different conditions, received treatment with intravenous disodium pamidronate in doses ranging from 0.5 to 12 mg/kg/y.

Results: Each child had rapid pain relief following the first treatment, followed by large increments in lumbar spine bone density over one year; the change in bone density standard deviation score ranged from 0.5 to 2.5 with percentage increments of 26% to 54%.

Conclusion: Intravenous pamidronate appears to be a useful therapeutic option in childhood osteoporosis, but its use in children must still be regarded as experimental and therefore closely monitored.

PubMed Disclaimer

Comment in

References

    1. J Clin Endocrinol Metab. 1985 Nov;61(5):952-6 - PubMed
    1. J Pediatr. 1977 Dec;91(6):1011-4 - PubMed
    1. Am J Dis Child. 1991 Apr;145(4):457-62 - PubMed
    1. J Pediatr. 1991 May;118(5):703-7 - PubMed
    1. Clin Exp Rheumatol. 1991 Jan-Feb;9 Suppl 6:33-5 - PubMed

MeSH terms