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Review
. 1999:87:305-13.
doi: 10.1007/978-3-0348-8757-1_22.

Microparticulate drug delivery systems

I Genta  1 , P Perugini, F Pavanetto, T Modena, B Conti, R A Muzzarelli
Affiliations
Review

Microparticulate drug delivery systems

I Genta et al. EXS. 1999.

Abstract

Chitosan was proposed as a drug carrier for mucosal administration in ocular, buccal, nasal, gastroenteric and vaginal-uterine therapies based on its bioadhesive properties and biodegradability in vivo under the action of hydrolases. Examples are the delivery of acyclovir via ocular administration, and the delivery of 5-aminosalicylic acid to the colon. Microparticles may need to be cross-linked to retard their degradation in acidic media; yet cross-linking with glutaraldehyde introduces cytotoxic characteristics and depresses bioadhesion. Alternative cross-linking approaches are discussed along with the suitability of chitosan for the oral delivery of vaccines.

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