Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Jul 24;150(2):F83-8.
doi: 10.1083/jcb.150.2.f83.

Drosophila melanogaster G protein-coupled receptors

T Brody  1 , A Cravchik
Affiliations
Review

Drosophila melanogaster G protein-coupled receptors

T Brody et al. J Cell Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Drosophila GPCR gene families. The newly identified GPCR genes are depicted in red. Left to right: gene name, defined transcript, closest Drosophila homologue, BLAST search e-values for the closest Drosophila (F), and C. elegans (W) and vertebrate (V) GPCRs. The # symbol indicates that the closest mammalian matches are from several different GPCR families. Previously identified Drosophila GPCRs (in black): (A) Rhodopsin-like: rhodopsins (Salcedo et al. 1999); mAcR-60C (Onai et al. 1989; Shapiro et al. 1989); dopamine receptors DopR and DopR2 (Gotzes et al. 1994; Feng et al. 1996); octopamine receptors: Ocr (Arakawa et al. 1990; Saudou et al. 1990) and Oamb (Han et al. 1998); serotonin receptors: 5-HT1A and 5-HT1B (Witz et al. 1990; Saudou et al. 1992); 5-HT2 (Colas et al. 1995) and 5-HT7 (Saudou et al. 1990); AlstR (Birgul et al. 1999); rickets (Ashburner et al. 1999); GRHR (Hauser et al. 1998); Takr99D (Li et al. 1991); Takr86C (Monnier et al. 1992); and NepYr (Li et al. 1992). (B) Secretin-like receptor: Methuselah (Lin et al. 1998). (C) Metabotropic glutamate receptor: Glu-RA (Parmentier et al. 1996).
Figure 2
Figure 2
Phylogeny tree of the Methuselah-like subfamily performed using the neighbor-joining method.
Figure 3
Figure 3
Multiple sequence alignment of the mth-like receptors performed using Clustal X. The topology of the seven putative TM domains is indicated.
See this image and copyright information in PMC

References

    1. Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F. The genome sequence of Drosophila melanogaster . Science. 2000;287:2185–2195. - PubMed
    1. Arakawa S., Gocayne J.D., McCombie W.R., Urquhart D.A., Hall L.M., Fraser C.M., Venter J.C. Cloning, localization, and permanent expression of a Drosophila octopamine receptor. Neuron. 1990;4:343–354. - PubMed
    1. Ashburner M., Misra S., Roote J., Lewis S.E., Blazej R., Davis T., Doyle C., Galle R., George R., Harris N. An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogasterthe Adh region. Genetics. 1999;153:179–219. - PMC - PubMed
    1. Bainton R.J., Tsai L.T., Singh C.M., Moore M.S., Neckameyer W.S., Heberlein U. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila . Curr. Biol. 2000;10:187–194. - PubMed
    1. Bargmann C.I. Neurobiology of the Caenorhabditis elegans genome. Science. 1998;396:2028–2033. - PubMed

Substances