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. 2000 Jul 25;55(2):302-4.
doi: 10.1212/wnl.55.2.302.

Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies

P F Chinnery  1 , G A Taylor, N Howell, R M Andrews, C M Morris, R W Taylor, I G McKeith, R H Perry, J A Edwardson, D M Turnbull
Affiliations

Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies

P F Chinnery et al. Neurology. .

Abstract

The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.

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