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Review
. 1975 Feb 28;33(1):66-72.

Platelet heparin-neutralizing factor (platelet factor 4)

  • PMID: 1091019
Review

Platelet heparin-neutralizing factor (platelet factor 4)

E F Lüscher et al. Thromb Diath Haemorrh. .

Abstract

The heparin-neutralizing platelet factor (PF4) is released from platelets under the influence of inducers of aggregation and nucleotide-release in the form of a high-molecular weight complex. The heparin-neutralizing activity is carried by a basic protein of molecular weight 29,700, four of which combine with a proteoglycan carrier, which in turn consists of 4 chondroitin sulfate A residues and a peptide moiety.

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