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Clinical Trial
. 2000 Mar;17(3):174-7.
doi: 10.1023/a:1009474307376.

Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: a prospective, randomized study

Y Y Hsieh  1 , H D Tsai, C C Chang, H Y Lo, C L Chen
Affiliations
Clinical Trial

Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: a prospective, randomized study

Y Y Hsieh et al. J Assist Reprod Genet. 2000 Mar.

Abstract

Purpose: The objective was to evaluate the effect of aspirin on infertile women with thin endometrium.

Methods: Patients who had thin endometrium (< or = 8 mm) and intrauterine insemination were divided into the aspirin and nonaspirin groups. Endometrial pattern (trilaminar and nontrilaminar) and thickness, the pulsatility index (PI) and resistance index (RI) of the uterine artery, spiral artery, and ovarian dominant follicles, and pregnancy rates of both groups were measured.

Results: A total of 114 and 122 women were included in the aspirin and nonaspirin groups, respectively. There were significantly higher percentages of trilaminar endometrium (46.5% vs. 26.2%) and pregnancy rate (18.4% vs. 9.0%) after aspirin therapy. There was nonsignificant difference in the endometrial thickness, and PI/RI values of the uterine artery, spiral artery, and ovarian dominant follicle between both groups.

Conclusions: Higher pregnancy rate and better endometrial pattern were achieved in patients with thin endometrium after aspirin administration. Aspirin therapy could not significantly increase the endometrial thickness and the resistance of uterine and ovarian flow.

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References

    1. Abdalla HI, Brooks AA, Johnson MR, Kirkland A, Thomas A, Studd JWW. Endometrial thickness: A predictor of implantation in ovum recipients? Hum Reprod. 1994;9:363–365. - PubMed
    1. Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: Prospective, randomized study. Fertil Steril. 1997;68:927–930. - PubMed
    1. Steer CV, Tan SL, Dillon D, Mason BA, Campbell S. Vaginal color Doppler assessment of uterine artery impedance correlates with immunohistochemical markers of endometrial receptivity required for the implantation of an embryo. Fertil Steril. 1995;63:101–108. - PubMed
    1. Kuo HC, Hsu CC, Wang ST, Huang KE. Aspirin improves uterine blood flow in the peri-implantation period. J Formos Med Assoc. 1997;96:253–257. - PubMed
    1. Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod. 1994;9:1954–1957. - PubMed

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