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Review
. 2000:20 Suppl 2:S19-25.

Neoangiogenesis in the peritoneal membrane

R T Krediet  1 , M M Zweers, A C van der Wal, D G Struijk
Affiliations
  • PMID: 10911638
Review

Neoangiogenesis in the peritoneal membrane

R T Krediet et al. Perit Dial Int. 2000.

Abstract

Objective: This study reviews relevant publications on the peritoneal vasculature and tries to establish morphological-functional relationships.

Design: The design is a review article.

Results: Recent morphological studies in peritoneal dialysis (PD) patients have shown the presence of diabetiform neoangiogenesis in long-term peritoneal dialysis. The same abnormalities could be induced in rats administered a high glucose dialysis solution daily for 20 weeks. The animals showed functional abnormalities in peritoneal transport similar to those found in long-term PD patients. Evidence was obtained in patients that vascular endothelial growth factor could be involved in glucose-induced peritoneal neoangiogenesis.

Conclusions: Diabetiform peritoneal neoangiogenesis is an important pathogenetic factor in ultrafiltration failure in long-term peritoneal dialysis patients.

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