doi: 10.1016/s0960-894x(00)00299-7.
Enhanced binding of aminoglycoside dimers to a "dimerized" A-site 16S rRNA construct
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- PMID: 10915059
- DOI: 10.1016/s0960-894x(00)00299-7
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Enhanced binding of aminoglycoside dimers to a "dimerized" A-site 16S rRNA construct
Bioorg Med Chem Lett.
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Abstract
In this work, we investigated the binding of a series of dimeric aminoglycoside molecules to (i) a 27 nt A-site 16S rRNA construct, and (ii) an artificially grafted 46 nt 'dimerized' A-site 16S rRNA construct. It was observed that the dissociation constants of dimeric aminoglycosides to the dimerized A-site 16S rRNA construct can achieve up to approximately 19-fold enhancement compared to the monomeric aminoglycoside molecules.
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