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Review
. 2000 Aug;25(8):352-6.
doi: 10.1016/s0968-0004(00)01589-9.

Maturation of cellular Fe-S proteins: an essential function of mitochondria

R Lill  1 , G Kispal
Affiliations
Review

Maturation of cellular Fe-S proteins: an essential function of mitochondria

R Lill et al. Trends Biochem Sci. 2000 Aug.

Abstract

Iron-sulfur (Fe-S) cluster-containing proteins perform important tasks in catalysis, electron transfer and regulation of gene expression. In eukaryotes, mitochondria are the primary site of cluster formation of most Fe-S proteins. Assembly of the Fe-S clusters is mediated by the iron-sulphate cluster assembly (ISC) machinery consisting of some ten proteins.

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