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Clinical Trial
. 2000 Jul 15;70(1):213-6.

Association of human herpesvirus 7 with cytomegalovirus disease in renal transplant recipients

C Y Tong  1 , A Bakran, H Williams, C Y Cheung, J S Peiris
Affiliations
  • PMID: 10919606
Clinical Trial

Association of human herpesvirus 7 with cytomegalovirus disease in renal transplant recipients

C Y Tong et al. Transplantation. .

Abstract

Background: Recent studies have linked human herpesviruses 6 (HHV-6) and 7 (HHV-7) with posttransplant cytomegalovirus (CMV) disease.

Methods: Thirty-seven renal transplant recipients were monitored weekly for CMV, HHV-6, and HHV-7 DNA and serological responses for 12 weeks after transplantation. Plasma CMV load and the occurrence of CMV disease was related to HHV-6 and -7 detection.

Results: CMV disease was identified in 12 patients. In a logistic regression analysis, factors significantly associated with CMV disease were the detection of HHV-7 DNA in peripheral blood leucocytes and donorrecipient CMV serostatus. Patients with detectable HHV-7 DNA had significantly higher peak plasma CMV loads (P=0.01).

Conclusions: An association was found between HHV-7, but not HHV-6, DNA detection and CMV disease, suggesting a possible role of HHV-7 in its pathogenesis.

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