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Clinical Trial
. 2000 Jul;183(1):58-62.
doi: 10.1067/mob.2000.105900.

Increase in serum leptin concentrations among women with endometriosis during danazol and leuprolide depot treatments

I M Matalliotakis  1 , Y G Koumantaki, M A Neonaki, A G Goumenou, G E Koumantakis, D S Kyriakou, E E Koumantakis
Affiliations
Clinical Trial

Increase in serum leptin concentrations among women with endometriosis during danazol and leuprolide depot treatments

I M Matalliotakis et al. Am J Obstet Gynecol. 2000 Jul.

Abstract

Objective: This study was undertaken to evaluate serum leptin concentrations in women with endometriosis during treatment with danazol and with leuprolide depot.

Study design: Twenty patients aged 18 to 42 years with regular menses and documented pelvic endometriosis were recruited from a university hospital setting. Treatment was 200 mg danazol 3 times daily for 6 months or 3.75 mg leuprolide depot every 28 days for 6 months. Serum leptin concentrations were measured before, during, and after treatment. A single blood sample was taken from each of 10 control women without endometriosis for comparison. Serum leptin level was measured with a radioimmunoassay kit with human leptin, and analysis of variance and paired t tests were used for statistical analysis.

Results: Serum leptin levels were almost the same among women with endometriosis as in the control group. Leptin levels were higher among women with endometriosis during treatment with danazol and leuprolide(P <.001). Three months after treatment, leptin values remained moderately higher than before treatment.

Conclusion: Danazol and leuprolide increased serum leptin levels. The mechanism of leptin increase is unclear. Further studies are needed to determine whether an adipogonadal axis exists.

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