Clinical Trial
The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits
- PMID: 1092111
Item in Clipboard
Clinical Trial
The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits
Acta Chir Scand.
1975.
Abstract
Inhibitors of the platelet functions, collagen-induced aggregation and release reaction (ASA and sulfinpyrazone) and ADP-induced aggregation (dipyridamole and VK 744), were investigated as potential preventive agents against venous thrombosis formation in rabbits. An experimental model combining endothelial damage (sodium morrhuate) and controlled stasis of the femoral venous flow was used. None of the agents showed any significant protective effect against venous thrombosis, a finding which is in keeping with the results of recent clinical investigation.
Similar articles
-
Antiplatelet agents: rationale and results.Clin Haematol. 1983 Feb;12(1):311-54. Clin Haematol. 1983. PMID: 6132693 Review. No abstract available.
-
[Action mechanism and clinical indications for thrombocyte aggregation inhibitors].Schweiz Med Wochenschr. 1979 Mar 10;109(10):348-53. Schweiz Med Wochenschr. 1979. PMID: 424707 German.
-
[Experimental platelet aggregation and arterial thrombosis. Effect of aspirin].Nouv Presse Med. 1973 Jun 23;2(25):1687-92. Nouv Presse Med. 1973. PMID: 4718537 French. No abstract available.
-
In vitro evaluation of inhibitors of platelet release and aggregation.Arch Surg. 1975 Aug;110(8):980-3. doi: 10.1001/archsurg.1975.01360140124024. Arch Surg. 1975. PMID: 168838
-
[Blood platelets and cardiovascular diseases. IV. Platelet-inhibiting drugs and antithrombotic agents].Union Med Can. 1976 Aug;105(8):1159-73. Union Med Can. 1976. PMID: 10662 Review. French. No abstract available.
Cited by
-
Characterization and antithrombotic action of tissue plasminogen activator.Experientia. 1984 Jan 15;40(1):67-8. doi: 10.1007/BF01959105. Experientia. 1984. PMID: 6229416
-
Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.Br J Pharmacol. 1982 May;76(1):3-31. doi: 10.1111/j.1476-5381.1982.tb09186.x. Br J Pharmacol. 1982. PMID: 7044460 Free PMC article. Review. No abstract available.