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. 2000 Jul 28;478(1-2):84-8.
doi: 10.1016/s0014-5793(00)01835-4.

Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

L J García-Rodriguez  1 , J A Trilla, C Castro, M H Valdivieso, A Durán, C Roncero
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Free article

Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

L J García-Rodriguez et al. FEBS Lett. .
Free article

Abstract

Deletion of the 1,3-beta-D-glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main components of the CSIII active complex.

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