HTLV-I transmission from mother to child

Abstract

Human T-lymphotropic virus type I (HTLV-I), a causative agent of adult T-cell leukemia, (ATL) is transmitted from mother to child. ATL cells originate from the CD4 subset of peripheral T cells. The main route of mother-to-child transmission is postnatal breast-feeding. Refraining from breast-feeding or limiting the duration of breast-feeding can reduce the risk of mother-to-child transmission. Other than postnatal breast-feeding, there seem to be two routes of HTLV-I transmission from mother to child. One is intrauterine transmission, and the other is via saliva. Intrauterine transmission is rare, although proviral DNA is detected in cord blood samples. HTLV-I proviruses in the cord blood may be defective. HTLV-I proviral DNA and antibodies against HTLV-I are also detected in saliva. However, no report has been published so far which showed direct evidence of HTLV-I transmission via saliva. The placenta can be infected by HTLV-I, but infection does not reach the fetus, possibly apoptosis of placental villous cells because it is induced by HTLV-I infection.