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. 2000 Apr;38(4):331-4.
doi: 10.1515/CCLM.2000.048.

Evaluation of the ADVIA Centaur TSH-3 assay

M Vogeser  1 , M Weigand, P Fraunberger, H Fischer, P Cremer
Affiliations

Evaluation of the ADVIA Centaur TSH-3 assay

M Vogeser et al. Clin Chem Lab Med. 2000 Apr.

Abstract

An analytical evaluation of the thyroid stimulating hormone (TSH-3) assay on the Bayer ADVIA Centaur immunoassay system was performed. General analytical requirements (linearity, resistance to typical interferences, absence of a carry-over effect) were fulfilled and reproducibility was satisfactory. Inter-assay coefficient of variation (CV) of a human serum pool with a concentration of 0.014 mU/l was 22.3%; at concentrations between 0.26 and 83 mU/l CV was below 6%. Method comparison study demonstrated close agreement of TSH results compared to those obtained with the Roche Elecsys 2010 TSH assay (ADVIA Centaur = 1.08 x Elecsys - 0.18 mU/l; r=0.987; n=324). Handling and practicability of the ADVIA Centaur system proved to be convenient with a very high sample throughput. We conclude that the ADVIA Centaur TSH-3 assay meets requirements for clinical use.

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