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. 1979 May 15;35(5):589-91.
doi: 10.1007/BF01960335.

alpha-Amanitin: inactivation by bovine lactoperoxidase

P W Morris, K M Kelley, W G Logas

alpha-Amanitin: inactivation by bovine lactoperoxidase

P W Morris et al. Experientia. .

Abstract

The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.

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