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. 1975 Mar;72(3):1059-62.
doi: 10.1073/pnas.72.3.1059.

N-formylmethionyl peptides as chemoattractants for leucocytes

E Schiffmann, B A Corcoran, S M Wahl

N-formylmethionyl peptides as chemoattractants for leucocytes

E Schiffmann et al. Proc Natl Acad Sci U S A. 1975 Mar.

Abstract

Leucocytes such as neutrophils are attracted by N-formylmethionine, but not by methionine. Di- and tripeptides containing formylmethionine are strong attractants for both neutrophils and macrophages, whereas the corresponding nonacylated compounds are not chemotactic. The formylated peptides may be related to an incompletely characterized chemotactic material normally produced by bacteria which attract the same animal cells.

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