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. 1975 Apr;72(4):1354-8.
doi: 10.1073/pnas.72.4.1354.

Proposal concerning mechanism of evolution of the genome of Escherichia coli

D Zipkas, M Riley

Proposal concerning mechanism of evolution of the genome of Escherichia coli

D Zipkas et al. Proc Natl Acad Sci U S A. 1975 Apr.

Abstract

Many pairs of genes whose gene products are functionally related lie either 90 degrees or 180 degrees apart on the circular map of the E. coli chromosome. A mechanism of evolution is proposed that involves two sequential duplications of an ancestral genome, followed by mutation and divergence of function of replicate genes.

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References

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