[Polymorphism of human alleles associated with genetic resistance against HIV-1 infection and its implications]

Abstract

To investigate the genetic susceptibility of different ethnic populations to human immunodeficiency virus-1(HIV-1) infection by comparing the characteristics of gene mutation frequency and polymorphism of CCR5, CCR2 and SDF-1 alleles among different nationalities in the world. The recently reported data on AIDS progression in patients, and on gene mutation and polymorphism of CCR5, CCR2b and SDF-1 genes were collected. The data also included the HIV-1-associated genes polymorphisms of the Chinese individuals detected by the present authors. There was a significant link between the gene mutation, polymorphism of HIV-1-associated genes, genetic susceptibilities and the AIDS progression in patients, although the differences of HIV-1-associated gene mutation, polymorphisms existed among different ethnic populations in the world. The Chinese individuals are more likely to be infected by the M-tropic HIV-1 strain than the American Caucasian. The Chinese individuals have very low gene mutation of CCR5Delta32, which would be helpful for the prevention and gene therapy against the HIV-1 infection.