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. 2000 Aug;25(4):376-7.
doi: 10.1038/78044.

The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei  1 , G P Hemmings
Affiliations

The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei et al. Nat Genet. 2000 Aug.

Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

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