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Review
. 2000 Aug;6(8):849-51.
doi: 10.1038/78592.

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

W E Wright  1 , J W Shay
Affiliations
Review

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

W E Wright et al. Nat Med. 2000 Aug.

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

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