Comment
doi: 10.1038/77900.
Intimate details of the most poisonous poison
- PMID: 10932240
- DOI: 10.1038/77900
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Comment
Intimate details of the most poisonous poison
Nat Struct Biol.
2000 Aug.
Abstract
Crystal structures of type B botulinum neurotoxin, determined under conditions relevant to the extracellular binding and intracellular substrate cleavage steps of its toxic action, reveal that minimal structural changes occur upon binding a ganglioside or after substrate cleavage. The unique structure of this toxin provides information for developing preventive measures against botulism.
Comment on
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Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.Nat Struct Biol. 2000 Aug;7(8):687-92. doi: 10.1038/77997. Nat Struct Biol. 2000. Retraction in: Nat Struct Mol Biol. 2009 Jul;16(7):795. doi: 10.1038/nsmb0709-795. PMID: 10932255 Retracted.
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Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B.Nat Struct Biol. 2000 Aug;7(8):693-9. doi: 10.1038/78005. Nat Struct Biol. 2000. PMID: 10932256
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