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Review
. 2000 May:25 Suppl 2:S54-7.
doi: 10.1038/sj.bmt.1702356.

Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man

S Slavin  1 , R Or, T Prighozina, O Gurevitch, M Aker, S Panighari, M Shapira, A Nagler
Affiliations
Review

Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man

S Slavin et al. Bone Marrow Transplant. 2000 May.

Abstract

Following engraftment of donor hematopoietic cells and induction of host-versus-graft tolerance, immunocompetent lymphocytes of donor origin can induce graft-versus-leukemia (GVL) and graft-versus-tumor (GVT) effects. Engraftment of allogeneic bone marrow cells can be accomplished following non-myeloablative conditioning while possibly controlling graft-versus-host disease (GVHD). GVL and GVT effects may thus be successfully accomplished following non-myeloablative stem cell transplantation (NST) as shown by data derived from experimental animals and man.

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