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Review
. 1997 Oct;2(4):335-42.
doi: 10.1023/a:1026391128117.

A specific role for cyclin D1 in mammary gland development

P Sicinski  1 , R A Weinberg
Affiliations
Review

A specific role for cyclin D1 in mammary gland development

P Sicinski et al. J Mammary Gland Biol Neoplasia. 1997 Oct.

Abstract

Cyclin D1 is a critical component of the core cell cycle machinery. Mice lacking cyclin D1 develop mammary glands that fail to undergo normal lobuloalveolar proliferation during pregnancy. Thus, cyclin D1 seems to play a critical role in pregnancy-induced proliferation of mammary epithelium. Cyclin D1 also participates in neoplasia, as the majority of human mammary carcinomas contain elevated levels of this cyclin.

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