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. 2000 May;27(4):407-14.
doi: 10.1016/s0969-8051(00)00090-1.

Imaging Tc-99m-labeled FGF-1 targeting in rats

K R Zinn  1 , S Kelpke, T R Chaudhuri, T Sugg, J M Mountz, J A Thompson
Affiliations

Imaging Tc-99m-labeled FGF-1 targeting in rats

K R Zinn et al. Nucl Med Biol. 2000 May.

Abstract

Recombinant human acidic fibroblast growth factor (FGF-1) was radiolabeled with (99m)Tc by the HYNIC method. The (99m)Tc-FGF-1 retained its representative molecular mass, heparin affinity, cellular binding to both low (Kd = 9.5 nM) and high (Kd = 125 pM) affinity sites, and mitogenic activity. Gamma camera imaging after intravenous dosing in rats confirmed high liver and kidney binding. Heparin significantly decreased (99m)Tc-FGF-1 liver uptake and increased urinary excretion. These studies illustrate a new method for imaging FGF-1 targeting under various conditions.

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