Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000:78 Suppl 2:105-8.

Molecular genetics of H

R Oriol  1 , J J Candelier, R Mollicone
Affiliations
  • PMID: 10938937
Review

Molecular genetics of H

R Oriol et al. Vox Sang. 2000.

Abstract

Background and objectives: Formal genetics of ABO, H-h and Se-se systems illustrate that these three systems are genetically independent

Materials and methods: Population analysis of phenotypes and family segregation of the ABH related genetic markers

Results: Inactivating mutations of FUT1 and FUT2 are compatible with a structural gene model assuming that FUT1 and FUT2 genes encode for two distinct enzymes, one encoding for the H antigen expressed in red cells (FUT1) and the other encoding for the H gene expressed in saliva (FUT2)

Conclusion: Most inactivating mutations of FUT1 and FUT2 genes are located in the coding region of the genes and are nonprevalent sporadic mutations of relative recent appearance.

PubMed Disclaimer

Publication types

LinkOut - more resources