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Comment
. 2000 Jul 21;289(5478):401-2.
doi: 10.1126/science.289.5478.401.

RNA structure. Ribozyme evolution at the crossroads

G F Joyce  1
Collaborators, Affiliations
Comment

RNA structure. Ribozyme evolution at the crossroads

G F Joyce. Science. .

Abstract

Molecules that have similar sequences usually adopt the same structures and have the same functions. In his Perspective, Joyce explains that this is not always the case. In a remarkable study (Schultes and Bartel), an RNA sequence has been designed that can adopt two different structures, each with a different catalytic function. Joyce details how this study sheds light on the evolution of enzymes.

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