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. 2000 Aug;15(8):542-50.
doi: 10.1046/j.1525-1497.2000.03499.x.

Prevalence and duration of postmenopausal hormone replacement therapy use in a managed care organization, 1990-1995

M T Connelly  1 , M Richardson, R Platt
Affiliations

Prevalence and duration of postmenopausal hormone replacement therapy use in a managed care organization, 1990-1995

M T Connelly et al. J Gen Intern Med. 2000 Aug.

Abstract

Objective: To determine the prevalence and duration of postmenopausal hormone replacement therapy (HRT) use and identify correlates of adherence to therapy.

Design: Population-based cohort study.

Setting: Staff-model health maintenance organization.

Participants: Female members, 40 years and older.

Measurements and main results: Prevalence and duration of use were measured between 1990 and 1995. Duration was assessed by Kaplan-Meier and proportional hazards methods. Hormone replacement therapy use increased from 10.3% in 1990 to 20.7% in 1995. Greatest use (24%) occurred among menopausal women age 50 to 54 years. Less than 5% of women 75 and older used HRT. Among 1,680 first-time recipients of HRT, two thirds of initial prescriptions were written by internists. Thirty-eight percent discontinued HRT within 1 year. For the subset whose indication for therapy was ascertained, prevention of chronic disease was associated with a 33% 1-year discontinuation rate. Factors associated with longer duration of therapy included white race (relative risk [RR], 1.63; 95% confidence interval [95% CI], 1.32 to 2.02), younger age (RR, 1.02 per year; 95% CI 1.01 to 1.03), and changing the preparation or dose of estrogen (RR, 5.62; 95% CI, 4.33 to 7.25). The formulation (esterified estrogens 0.625 mg versus conjugated estrogens 0.625 mg) was also associated with greater duration of use; all other estrogens were, as a group, associated with shorter duration of use. Those who received their initial HRT prescription from an internist were more likely to continue therapy than those who received it from a gynecologist.

Conclusions: Despite increased use of HRT, only a minority of women in this population used HRT, and many of those discontinued therapy within 1 year.

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Figures

FIGURE 1
FIGURE 1
Prevalence of hormone replacement therapy use among menopausal women 45 and older, 1990–1995.
FIGURE 2
FIGURE 2
Proportion using hormone replacement therapy by age, 1990–1995.
FIGURE 3
FIGURE 3
Time to discontinuation of hormone replacement therapy (HRT).
FIGURE 3
FIGURE 3
Time to discontinuation of hormone replacement therapy (HRT).
See this image and copyright information in PMC

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References

    1. Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. 1992;117:1016–37. - PubMed
    1. Grodstein F, Stampfer MJ, Manson JE, et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 1996;335:453–61. - PubMed
    1. Stampfer MJ, Colditz GA, Willett WC, et al. Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the Nurses' Health Study. N Engl J Med. 1991;325:756–62. - PubMed
    1. Cauley JA, Seeley DG, Ensrud K, Ettinger B, Black D, Cummings SR. Estrogen replacement therapy and fractures in older women. Ann Intern Med. 1995;122:9–16. - PubMed
    1. Henderson BE, Paganini-Hill A, Ross RK. Decreased mortality in users of estrogen replacement therapy. Arch Intern Med. 1991;151:75–8. - PubMed

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