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. 2000 Aug;183(2):431-7.
doi: 10.1067/mob.2000.105738.

Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion

G G Donders  1 , B Van Bulck, J Caudron, L Londers, A Vereecken, B Spitz
Affiliations

Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion

G G Donders et al. Am J Obstet Gynecol. 2000 Aug.

Abstract

Objective: This study was undertaken to investigate a possible link between first-trimester diagnosis of bacterial vaginosis and cessation of pregnancy at < or =20 weeks' gestation.

Study design: Women (n = 228) who received routine prenatal care in Flanders, Belgium, during the first trimester (14 weeks' gestation) and had a living singleton fetus were examined for microbiologic flora of the vagina. Bacterial vaginosis was assessed either clinically (Amsel et al criteria), microscopically (clue cells), or by culture of bacterial vaginosis-associated bacteria. Data were analyzed univariately (relative risk) and multivariately.

Results: The presence of bacterial vaginosis at the first prenatal visit was strongly associated with subsequent early pregnancy loss (relative risk, 5.4; 95% confidence interval, 2.5-11). After multivariate analysis bacterial vaginosis, Mycoplasma hominis, and Ureaplasma urealyticum but not other microorganisms remained associated with an increased risk of miscarriage.

Conclusion: Bacterial vaginosis and mycoplasmas may play causative roles in spontaneous abortion and early pregnancy loss.

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