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. 1975 Jun;72(6):2150-4.
doi: 10.1073/pnas.72.6.2150.

Novel mutants of Escherichia coli that accumulate very small DNA replicative intermediates

E B Konrad, I R Lehman

Novel mutants of Escherichia coli that accumulate very small DNA replicative intermediates

E B Konrad et al. Proc Natl Acad Sci U S A. 1975 Jun.

Abstract

A new group of mutants has been isolated which, during short pulses, incorporate (3-H)thymidine into DNA fragments that are substantially smaller than Okazaki fragments. These small fragments can be chased into DNA of high-molecular-weight, and thus may be precursors in DNA replication, During longer pulses, label also appears in DNA of higher molecular weight, although at an abnormally slow rate. The mutations map at a previously undescribed locus (dnaS) at 72 min on the E. coli chromosome.

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References

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