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. 2000 Aug;284(8):972-7.
doi: 10.1001/jama.284.8.972.

Low bone mineral density and risk of fracture in white female nursing home residents

J M Chandler  1 , S I Zimmerman, C J Girman, A R Martin, W Hawkes, J R Hebel, P D Sloane, L Holder, J Magaziner
Affiliations

Low bone mineral density and risk of fracture in white female nursing home residents

J M Chandler et al. JAMA. 2000 Aug.

Abstract

Context: Low bone mineral density (BMD) is a strong risk factor for fracture in community-dwelling white women, but the relationship in white female nursing home residents, for whom fracture rates are highest, is less clear.

Objective: To assess the relative contribution of low BMD to fracture risk in nursing home residents.

Design: Prospective cohort study with baseline data collected April 1995 to June 1997, with 18 months of follow-up.

Setting: Forty-seven randomly selected nursing homes in Maryland.

Patients: A total of 1427 white female nursing home residents aged 65 years or older.

Main outcome measure: Documented osteoporotic fracture occurring during follow-up as a function of baseline BMD measurements higher vs lower than the median, and after controlling for demographic, functional, cognitive, psychosocial, and medical factors.

Results: A total of 223 osteoporotic fractures occurred among 180 women. Low BMD and transfer independence were significant independent risk factors for fracture in this nursing home sample (P<.001) and the 2 factors acted synergistically (P =.06) to further increase fracture risk. Compared with women whose BMD was higher than the median (0. 296 g/cm(2)), those whose BMD was lower than the median had an unadjusted hazard ratio for risk of fracture of 2.1 (95% confidence interval [CI], 1.5-2.8); women who were independent in transfer had a hazard ratio of 1.6 (95% CI, 1.2-2.2) compared with women dependent in transfer. Among residents independent in transfer, those with BMD below the median had a more than 3-fold increase in fracture risk compared with those with higher BMD (unadjusted hazard ratio, 3.1; 95% CI, 2.2-4.4). Among residents dependent in transfer, those with BMD below the median had a 60% increase in fracture risk (unadjusted hazard ratio, 1.6; 95% CI, 1.1-2.3). Adjustment for covariates did not alter the BMD-fracture relationship.

Conclusions: Our data indicate that low BMD and independence in transfer are significant predictors of osteoporotic fracture in white female nursing home residents. JAMA. 2000;284:972-977

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