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. 2000 Jun;26(6):800-3.
doi: 10.1007/s001340051250.

Time course of oxidative stress after major burns

M Bertin-Maghit  1 , J Goudable, E Dalmas, J P Steghens, C Bouchard, P Y Gueugniaud, P Petit, B Delafosse
Affiliations

Time course of oxidative stress after major burns

M Bertin-Maghit et al. Intensive Care Med. 2000 Jun.

Abstract

Objective: To evaluate oxidative stress resulting from major burns in humans.

Design: Prospective clinical study with control group.

Setting: Mechanically ventilated adult patients admitted with more than 30% total burn surface area.

Patients and participants: 20 patients with a mean body surface burned area of 54%.

Measurements and results: The oxidative stress evaluation was based on measurements of trace elements, vitamins, antioxidant enzymatic activity and end-products of lipid peroxidation. During the first 5 days after injury burn patients exhibit a decrease in selenium and antioxidant vitamins (C, beta-carotene, lycopene) and an increase in lipid peroxidation products (TBARS).

Conclusion: Our results suggest that major burn is associated with oxidative stress during the 5 days after the initial injury, as demonstrated by a simultaneous decrease in antioxidant vitamins and a large increase in TBARS.

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