doi: 10.1002/1096-8628(20000814)93:4<290::aid-ajmg7>3.0.co;2-m.
Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26
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- PMID: 10946355
- DOI: 10.1002/1096-8628(20000814)93:4<290::aid-ajmg7>3.0.co;2-m
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Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26
Am J Med Genet.
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Abstract
Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at theta = 0 for markers DXS425, DXS1254, DXS1114, and HPRT.
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