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. 2000 Aug 14;93(4):290-3.
doi: 10.1002/1096-8628(20000814)93:4<290::aid-ajmg7>3.0.co;2-m.

Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26

R Caspari  1 , S Uhlhaas, W Friedl, M Knapp, P Propping
Affiliations

Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26

R Caspari et al. Am J Med Genet. .

Abstract

Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at theta = 0 for markers DXS425, DXS1254, DXS1114, and HPRT.

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