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Clinical Trial
. 1997 Apr;17(2):88-91.
doi: 10.1097/00004714-199704000-00004.

A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia

S Angus  1 , J Sugars, R Boltezar, S Koskewich, N M Schneider
Affiliations
Clinical Trial

A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia

S Angus et al. J Clin Psychopharmacol. 1997 Apr.

Abstract

An 18-week, double-blind, crossover study of amantadine and neuroleptics in the treatment of tardive dyskinesia (TD) is described. A fixed-dose regimen was used, and objective rating scales for TD, extrapyramidal symptoms, and mental state were employed. The results indicate that amantadine is significantly better than placebo in the management of TD and that there is little risk of exacerbating psychosis. Further investigation of this potentially useful medication is warranted.

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