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. 2000 Apr;9(2):145-54.
doi: 10.1023/a:1008983615045.

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

A S Chen  1 , J M Metzger, M E Trumbauer, X M Guan, H Yu, E G Frazier, D J Marsh, M J Forrest, S Gopal-Truter, J Fisher, R E Camacho, A M Strack, T N Mellin, D E MacIntyre, H Y Chen, L H Van der Ploeg
Affiliations

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

A S Chen et al. Transgenic Res. 2000 Apr.

Abstract

We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.

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