Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Aug;106(4):453-8.
doi: 10.1172/JCI10762.

Insulin resistance and cardiovascular disease

H N Ginsberg  1
Affiliations
Review

Insulin resistance and cardiovascular disease

H N Ginsberg. J Clin Invest. 2000 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A simplified model relating insulin resistance to dyslipidemia and cardiovascular disease. Insulin resistance at the adipocyte results in increased release of fatty acids into the circulation. A similar accumulation of fatty acids could arise from defects in fatty acid transporters or intracellular binding proteins. Increased FFA flux to the liver stimulates the assembly and secretion of VLDL resulting in hypertriglyceridemia. In addition, VLDL stimulates the exchange of cholesteryl esters from both HDL and LDL for VLDL TG. ApoA-I can dissociate from TG-enriched HDL. This free apoA-I is cleared rapidly from plasma, in part by excretion through the kidney, thus reducing the availability of HDL for reverse cholesterol transport. TG-enriched LDL can undergo lipolysis and become smaller and more dense. Low levels of HDL and the presence of small dense LDL are each independent risk factors for cardiovascular disease. IR, insulin resistance; CE, cholesteryl ester; SD, small dense.
See this image and copyright information in PMC

Comment in

References

    1. Albrink MJ, Krauss RM, Lindgren FT, Von der Groeben VD, Wood PDS. Intercorrelations among high density lipoproteins, obesity, and triglycerides in a normal population. Lipids. 1980;15:668–678. - PubMed
    1. Reaven GM, Lerner RL, Stern MP, Farquhar JW. Role of insulin in endogenous hypertriglyceridemia. J Clin Invest. 1967;46:1756–1767. - PMC - PubMed
    1. Howard G, et al. Insulin sensitivity and atherosclerosis. Circulation. 1996;93:1809–1817. - PubMed
    1. Miller GJ, Miller NE. Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet. 1975;1:16–19. - PubMed
    1. Welborn TA, Breckenridge A, Rubinstein AH, Dollery CT, Fraser TR. Serum-insulin in essential hypertension and in peripheral vascular disease. Lancet. 1966;1:1336–1337. - PubMed