Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Sep;21(9):455-64.
doi: 10.1016/s0167-5699(00)01692-3.

Antigen-processing machinery breakdown and tumor growth

B Seliger  1 , M J Maeurer, S Ferrone
Affiliations
Review

Antigen-processing machinery breakdown and tumor growth

B Seliger et al. Immunol Today. 2000 Sep.

Abstract

Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from in vitro recognition by T cells.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources