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. 2000 Aug;21(7):1354-8.

Localized proton MR spectroscopy of the allocortex and isocortex in healthy children

C G Choi  1 , T S Ko, H K Lee, J H Lee, D C Suh
Affiliations

Localized proton MR spectroscopy of the allocortex and isocortex in healthy children

C G Choi et al. AJNR Am J Neuroradiol. 2000 Aug.

Abstract

Background and purpose: The human allocortex is different from the isocortex in neuroglial cytoarchitecture. The purpose of this study was to compare metabolic data of the allocortex with those of the isocortex by using localized proton MR spectroscopy.

Methods: Short-TE stimulated-echo acquisition mode proton MR spectroscopy (TR/TE = 3000/30) was applied to the allocortex of the temporal lobe and isocortex of the parietal or frontal lobe in 30 healthy children (19 boys and 11 girls, 3-14 years old). Peak intensities of N-acetylaspartate (NAA), choline-containing compounds (Cho), and myo-inositol (mI) relative to creatine and phosphocreatine (Cr) were calculated. Metabolic data from the investigated regions were compared.

Results: NAA/Cr was significantly lower in the allocortex than in the isocortex of the parietal or frontal lobe: 1.05 +/- 0.12 (n = 33) vs. 1.36 +/- 0.10 (n = 28) or 1.32 +/- 0.10 (n = 12), respectively. Cho/Cr and mI/Cr were significantly higher in the allocortex than in the isocortex: 0.84 +/- 0.11 vs. 0.56 +/- 0.06 or 0.75 +/- 0.10; 0.78 +/- 0.15 vs. 0.54 +/- 0.08 or 0.66 +/- 0.09, respectively. In the isocortex, NAA/Cr was not different but Cho/Cr and mI/Cr were significantly higher in the frontal cortex than in the parietal cortex.

Conclusion: Clear metabolic differences were observed between the allocortex and isocortex.

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Figures

<sc>fig</sc> 1.
fig 1.
A and B, Coronal (A) and axial (B) T2-weighted MR images show typical locations selected for proton MR spectroscopy of the allocortex (A), parietal cortex, and frontal cortex (B)
<sc>fig</sc> 2.
fig 2.
A–C, Typical proton MR spectra obtained from the allocortex (A), parietal cortex (B), and frontal cortex (C). Acquisition and processing parameters used for all spectra are the same as described in the text, except for voxel sizes, which are 5.0 mL for the allocortex and 7.2 mL for the isocortex. All spectra are scaled individually and cannot be used for direct comparison. NAA, 2.01 ppm; Cr, 3.03 ppm; Cho, 3.22 ppm; mI, 3.56 ppm
<sc>fig</sc> 3.
fig 3.
Spectroscopic data plotted against age of the children. A, NAA/Cr vs. age. B, Cho/Cr vs. age. C, mI/Cr vs. age.
See this image and copyright information in PMC

Comment in

  • Redefining "normal".
    Ball WS Jr. Ball WS Jr. AJNR Am J Neuroradiol. 2000 Aug;21(7):1182-3. AJNR Am J Neuroradiol. 2000. PMID: 10954265 Free PMC article. No abstract available.

References

    1. Clemente CD. Developmental and gross anatomy of the central nervous system. In: Clemente CD, ed.Gray's Anatomy, 30th American ed. Philadelphia: Lea & Febiger 1985;1075-1082
    1. Breiter SN, Arroyo S, Mathews VP, Lesser RP, Bryan RN, Barker PB. Proton MR spectroscopy in patients with seizure disorders. AJNR Am J Neuroradiol 1994;15:373-384 - PMC - PubMed
    1. Ng TC, Comair YG, Xue M, et al. Temporal lobe epilepsy: presurgical localization with proton chemical shift imaging. Radiology 1994;193:465-472 - PubMed
    1. Lu D, Margouleff C, Rubin E, et al. Temporal lobe epilepsy: correlation of proton magnetic resonance spectroscopy and 18F-fluorodeoxyglucose positron emission tomography. Magn Reson Med 1997;37:18-23 - PubMed
    1. Woermann FG, McLean MA, Bartlett PA, Parker GJ, Duncan JS. Short-echo time single-voxel 1H magnetic resonance spectroscopy in magnetic resonance imaging-negative temporal lobe epilepsy: different biochemical profile compared with hippocampal sclerosis. Ann Neurol 1999;45:369-376 - PubMed

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