The primary antibacterial defense mechanism of the bladder
- PMID: 1095522
The primary antibacterial defense mechanism of the bladder
Abstract
We have developed a model in rabbits for quantitatively determining the attachment of microbial organisms to the vesical mucosa. Our data suggest that the bladder has a primary antibacterial defense mechanism that serves to interrupt microbial attachment. This mechanism seems to be secretory, since after destruction with acid, the resistance to microbial binding returns in less than 24 hr.
Similar articles
-
Bladder defense mechanism.Trans Am Assoc Genitourin Surg. 1976;68:83-6. Trans Am Assoc Genitourin Surg. 1976. PMID: 801214
-
Bladder surface mucin. Examination of possible mechanisms for its antibacterial effect.Invest Urol. 1978 Nov;16(3):196-200. Invest Urol. 1978. PMID: 30735
-
Vesical defense: further evidence for a charge-related mucosal anti-adherence mechanism.Surg Forum. 1978;29:632-3. Surg Forum. 1978. PMID: 401419 No abstract available.
-
Pathogenesis of urinary tract infections. Bacterial adherence, bladder defense mechanisms.Urol Clin North Am. 1986 Nov;13(4):563-8. Urol Clin North Am. 1986. PMID: 2877517 Review.
-
Interaction of uropathogenic Escherichia coli with host uroepithelium.Curr Opin Microbiol. 2005 Feb;8(1):54-9. doi: 10.1016/j.mib.2004.12.001. Curr Opin Microbiol. 2005. PMID: 15694857 Review.
Cited by
-
Prevention of urinary tract infection in rats with an indigenous Lactobacillus casei strain.Infect Immun. 1985 Aug;49(2):320-4. doi: 10.1128/iai.49.2.320-324.1985. Infect Immun. 1985. PMID: 3926645 Free PMC article.
-
Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis.Curr Urol Rep. 2006 Nov;7(6):440-6. doi: 10.1007/s11934-006-0051-8. Curr Urol Rep. 2006. PMID: 17052438 Review.
-
The Burden of Urinary Tract Infections on Quality of Life and Healthcare in Patients with Interstitial Cystitis.Healthcare (Basel). 2023 Oct 18;11(20):2761. doi: 10.3390/healthcare11202761. Healthcare (Basel). 2023. PMID: 37893834 Free PMC article.
-
The effect of vesical outlet obstruction on the protein secondary structure of the mucosa and serosa in rabbit bladder wall.Urol Res. 1994;22(4):205-8. doi: 10.1007/BF00541893. Urol Res. 1994. PMID: 7871630
-
Treatment of mice with staphylococcal enterotoxin B enhances resolution of an induced Escherichia coli urinary tract infection and stimulates production of proinflammatory cytokines.Infect Immun. 1998 Jun;66(6):2466-70. doi: 10.1128/IAI.66.6.2466-2470.1998. Infect Immun. 1998. PMID: 9596704 Free PMC article.