Pregnancy outcome in carriers of fragile X

Abstract

Objective: To evaluate pregnancy outcome in women who are carriers of fragile X.

Design: Cross-sectional case-control study.

Setting: Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.

Sample: Sixty-three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio University Hospital.

Methods: Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric population.

Results: Carriers of fragile X often experienced more bleeding in late pregnancy than did the reference group. Otherwise, the course and outcome of pregnancy were comparable in both groups.

Conclusion: Pregnancy outcome in women who are carriers of fragile X is favourable. There is no need to initiate special fetal monitoring because of the fragile X status of the woman.