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Clinical Trial
. 2000 Aug;18(3):265-7.
doi: 10.1023/a:1006434008357.

Phase II trial of pyrazoloacridine in patients with cisplatin-refractory germ cell tumors

J Vuky  1 , J McCaffrey, M Ginsberg, T Mariani, D F Bajorin, G J Bosl, R J Motzer
Affiliations
Clinical Trial

Phase II trial of pyrazoloacridine in patients with cisplatin-refractory germ cell tumors

J Vuky et al. Invest New Drugs. 2000 Aug.

Abstract

Thirteen patients with cisplatin-refractory germ cell tumors were treated on a Phase II trial with pyrazoloacridine. Pyrazoloacridine was given intravenously at 600 mg/m2 every three weeks. The median nadir leucocyte count was 2.5 cells/mm3, hemoglobin was 10.8 g/dl, and platelet count was 126,000 cells/m3. None of the thirteen evaluable patients achieved a major response. Pyrazoloacridine is not efficacious in the treatment of cisplatin-refractory germ cell tumors.

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References

    1. N Engl J Med. 1997 Jul 24;337(4):242-53 - PubMed
    1. J Clin Oncol. 1998 Jul;16(7):2500-4 - PubMed
    1. Cancer Invest. 1990;8(1):39-47 - PubMed
    1. J Clin Oncol. 1995 Aug;13(8):1975-84 - PubMed
    1. Cancer Res. 1987 Aug 15;47(16):4299-304 - PubMed

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