Synaptogenesis and structure of the autonomic ganglia

Abstract

The present study summarises the current data dealing with processes leading to the establishing of the synaptic architecture and connections with both the preganglionic neurons and target tissues of autonomic ganglia Starting from the migration point of the neural crest cells, the factors and mechanisms driving the development of the autonomic nervous system, axonal pathfinding and establishing of ganglionic connections, as well as formation and plasticity of autonomic synapses are reviewed with regard to their functional relevance in these processes. Furthermore, the chemical neuroanatomy and somatotopic arrangement of either the preganglionic, sympathetic or parasympathetic division of the autonomic nervous system are discussed from the morphological ¿and functional point of view.