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. 1975;18(1):131-5.
doi: 10.1159/000122391.

Modification of brain and CSF LH-RH following deafferentation

M Morris, B Tandy, D K Sundberg, K M Knigge

Modification of brain and CSF LH-RH following deafferentation

M Morris et al. Neuroendocrinology. 1975.

Abstract

The effect of hypothalamic deafferentation upon levels of LH-RH in brain, cerebrospinal fluid, and plasma was studied in adult male rats. Deafferentation produced a significant increase in the LH-RH concentration of third ventricular CSF (from 140.6 to 343.9 pg/microl), while there was no change in median eminence or hypothalamic content. LH-RH in the pineal gland and the posterior pituitary was also elevated by hypothalamic isolation.

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