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. 2000 Apr;19(4):749-56.
doi: 10.1080/15257770008035022.

Replacement of the phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme by an amide bond

M Dunkel  1 , V Reither
Affiliations

Replacement of the phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme by an amide bond

M Dunkel et al. Nucleosides Nucleotides Nucleic Acids. 2000 Apr.

Abstract

The phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme was substituted by an amide backbone without compromising the ribozyme's cleavage activity. Furthermore, the modified ribozyme proved to be completely stable against endonucleolytic digestion at this position.

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