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Review
. 2000 Jul 25;48(3):325-7.
doi: 10.1016/s0162-3109(00)00234-4.

Diesel exhaust as a model xenobiotic in allergic inflammation

A Saxon  1 , D Diaz-Sanchez
Affiliations
Review

Diesel exhaust as a model xenobiotic in allergic inflammation

A Saxon et al. Immunopharmacology. .

Abstract

We investigated the effects of diesel exhaust particulates on the human allergic response using in vivo human nasal challenges. Diesel particles and phenanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-specific IgE in the presence of allergen, and induce sensitization to a neoantigen.

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